YK-4-279 ( YK-4-279; YK4-279; YK 4-279; YK 4279 )

产品货号. M17770 CAS No. 1037184-44-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

YK-4-279
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

YK 4-279, an inhibitor of RNA Helicase A (RHA), binds to the oncogenic transciption factor EWS-FLI1.
产品描述

YK-4-279 is a ETV1 inhibitor, which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model.
同义词

YK-4-279; YK4-279; YK 4-279; YK 4279
通路

Others
靶点

Other Targets
受体

RNA helicase A
研究领域

Cancer
适应症

——

CAS Number

1037184-44-3
分子量

366.2
分子式

C17H13Cl2NO4
纯度

98%
溶解度

DMSO : 25 mg/mL. 68.27 mM;
SMILES

COC1=CC=C(C=C1)C(=O)CC1(O)C(=O)NC2=C(Cl)C=CC(Cl)=C12
化学全称

4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one

1. Erkizan HV, et al. Nat Med. 2009, 15(7), 750-756.2. Rahim S, et al. PLoS One. 2011, 6(4), e19343.

计算器

产品手册

关联产品

Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
Methyl nomilinate

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.