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XY101

CAS No. 2349368-16-5

XY101 ( —— )

产品货号. M26510 CAS No. 2349368-16-5

XY101 是一种选择性、代谢稳定、口服的 RORγ 逆激动剂(IC50 为 30 nM,Kd 为 380 nM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥2341 有现货
10MG ¥4026 有现货
25MG ¥6423 有现货
50MG ¥9153 有现货
100MG ¥12312 有现货
500MG ¥24057 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    XY101
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    XY101 是一种选择性、代谢稳定、口服的 RORγ 逆激动剂(IC50 为 30 nM,Kd 为 380 nM)。
  • 产品描述
    XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).(In Vitro):XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA).(In Vivo):XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss.
  • 体外实验
    XY101 potently inhibits cell growth, colony formation, and the expression of androgen receptor (AR), AR-V7 and prostate-specific antigen (PSA).
  • 体内实验
    XY101 exhibits significant antitumor activities during the treatment period with tumor growth inhibition and is well tolerated without obvious body weight loss.
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    α-synuclein
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2349368-16-5
  • 分子量
    563.49
  • 分子式
    C25H20F7NO4S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 250 mg/mL (443.67 mM)
  • SMILES
    CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)-c2ccc(cc2F)C(O)(C(F)(F)F)C(F)(F)F)cc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Pujols J, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10481-10486.
产品手册
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