XEN-907

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性 NaV1.7 阻断剂，IC50 为 3 nM。

A potent, selective NaV1.7 blocker with IC50 of 3 nM; shows no significant activity at 10 uM against a broad panel of 63 receptors and transporters; has no cytotoxic and favourable hepatocyte metabolic stability for both human and dog,Pain Preclinical.

XEN907 is not cytotoxic in HepG2 cells (% viable after 16 h: >99%).XEN907 shows moderate hepatocyte stability (% remaining after 2 h: rat 21%; human 34%; dog 46%) across species.

XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), Cmax (35 ng/mL), and AUClast (143 h?ng/mL) in rats.XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats.

XEN907 | XEN 907

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

Pain

912656-34-9

351.3958

C21H21NO4

>98% (HPLC)

10 mM in DMSO

O=C(C12COC3=C1C=C(OCO4)C4=C3)N(CCCCC)C5=C2C=CC=C5

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-

(-20℃)

With Ice Pack

≥ 2 years