
Wogonin
CAS No. 632-85-9
Wogonin ( BRN 0287152 )
产品货号. M15392 CAS No. 632-85-9
汉黄芩素是一种天然存在的单黄酮类化合物,可以抑制CDK8和Wnt的活性,并具有抗炎和抗肿瘤作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | ¥1134 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Wogonin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述汉黄芩素是一种天然存在的单黄酮类化合物,可以抑制CDK8和Wnt的活性,并具有抗炎和抗肿瘤作用。
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产品描述Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.(In Vitro):Wogonin (0-200 μM) exhibits a dose- and time- dependent reduces in cell viability of caco-2, SW1116 and HCT116 cells. Wogonin (10-40 μM) induces G1 phase arrest in HCT-116 cells. Wogonin also supresses Wnt signaling pathway in HCT116 cells. Wogonin interfers in the activity of transcription factor TCF/Lef family. Moreover, Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8. Wogonin shows cytotoxic and antiproliferative effects on HeLa cells. Wogonin (90 μM) induces cell cycle arrest at G0-G1 phase, and suppresses the levels of cyclin D1 and Cdk4 markedly in HeLa cells. Wogonin (1.25, 2.5, 5, 10, 20 μg/ml) suppresses EtOH-induced inflammatory response in RAW264.7 cells.(In Vivo):Wogonin (30, 60 mg/kg) reduces tumor growth of HCT116 cells in a xenograft model. Wogonin (25, 50, 100 mg/kg) protects against liver injury and pathological characteristics of ALD in mice. Wogonin activates PPAR-γ expression in mice with ALD and EtOH induced RAW264.7 cells.
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体外实验——
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体内实验——
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同义词BRN 0287152
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通路Others
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靶点Other Targets
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受体Others
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number632-85-9
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分子量284.26
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分子式C16H12O5
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纯度>98% (HPLC)
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溶解度DMSO: 10 mM
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SMILESO=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13
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化学全称4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhao Y, et al. Mol Carcinog. 2015 Jun;54 Suppl 1:E81-93.
产品手册




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