WYE-687 ( WYE687; WYE 687; WYE-687 )

产品货号. M17132 CAS No. 1062161-90-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

WYE-687
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308).
产品描述

WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
同义词

WYE687; WYE 687; WYE-687
通路

Others
靶点

Other Targets
受体

mTOR , PI3Kα , PI3Kγ , p38α , Src
研究领域

Cancer
适应症

——

CAS Number

1062161-90-3
分子量

528.61
分子式

C28H32N8O3
纯度

98%
溶解度

——
SMILES

COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6
化学全称

methyl (4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)carbamate

1. Yu K, et al, Cancer Res, 2009, 69(15), 6232-6240.

计算器

产品手册

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