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WS-6
CAS No. 1421227-53-3
WS-6 ( WS6 | WS 6 )
产品货号. M11760 CAS No. 1421227-53-3
一种可诱导β细胞增殖的小分子，EC50为0.28 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥348 | 有现货 |
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| 5MG | ￥535 | 有现货 |
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| 10MG | ￥891 | 有现货 |
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| 25MG | ￥1798 | 有现货 |
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| 50MG | ￥3281 | 有现货 |
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| 100MG | ￥4131 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称WS-6
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种可诱导β细胞增殖的小分子，EC50为0.28 uM。
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产品描述A small molecule that can induce proliferation of β cells with EC50 of 0.28 uM; promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation; acts by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription; also stimulates α cell proliferation in human pancreatic islets.
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体外实验——
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体内实验——
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同义词WS6 | WS 6
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通路Immunology/Inflammation
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靶点IκB kinase (IKK)
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受体ErbB3-BindingProtein-1(EBP2)|IκBkinase
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number1421227-53-3
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分子量568.59
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分子式C29H31F3N6O3
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)CC3=CC=C(OC4=NC=NC(NC(C5CC5)=O)=C4)C=C3
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化学全称Benzeneacetamide, 4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.
产品手册
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