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WS-3
CAS No. 1421227-52-2
WS-3 ( WS3 | WS 3 )
产品货号. M11759 CAS No. 1421227-52-2
一种小分子，可诱导 β 细胞增殖，EC50 为 74 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥356 | 有现货 |
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| 10MG | ￥567 | 有现货 |
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| 25MG | ￥1021 | 有现货 |
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| 50MG | ￥1823 | 有现货 |
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| 100MG | ￥3362 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称WS-3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种小分子，可诱导 β 细胞增殖，EC50 为 74 nM。
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产品描述A small molecule that can induce proliferation of β cells with EC50 of 74 nM; modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway; can reversibly proliferates primary RPE cells isolated from fetal and adult human donors.
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体外实验WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM.WS3 (1.0 nM-1.0 μM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.
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体内实验——
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同义词WS3 | WS 3
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通路Immunology/Inflammation
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靶点IκB kinase (IKK)
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受体ErbB3-BindingProtein-1(EBP1)|IκBkinase
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number1421227-52-2
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分子量569.5781
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分子式C28H30F3N7O3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 43 mg/mL
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SMILESCN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
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化学全称Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.
