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WIN-18446
CAS No. 1477-57-2
WIN-18446 ( WIN18446 | WIN 18446 )
产品货号. M12038 CAS No. 1477-57-2
一种有效的、共价的、口服活性的 ALDH1A2 抑制剂，IC50 为 0.3 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥308 | 有现货 |
|
| 25MG | ￥494 | 有现货 |
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| 50MG | ￥721 | 有现货 |
|
| 100MG | ￥1037 | 有现货 |
|
| 500MG | ￥2641 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称WIN-18446
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的、共价的、口服活性的 ALDH1A2 抑制剂，IC50 为 0.3 uM。
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产品描述A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM; potently inhibits spermatogenesis and causes infertility in vivo by inhibiting retinoic acid synthesis.
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体外实验RT-PCR Cell Line:Testes were collected from 2-dpp mice.Concentration:1 μM.Incubation Time:24 h.Result:Results in a VAD-like phenotype in the testis.Alone or in combination with ROL significantly reduced Stra8 expression.
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体内实验Animal Model:Six-month-old male New Zealand white rabbits.Dosage:200 mg/kg.Administration:Orally for 4, 8, and 16 weeks.Result:Resulted in marked suppression of testicular weight over time.Dramatically suppressed spermatogenesis.Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.
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同义词WIN18446 | WIN 18446
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通路Metabolic Enzyme/Protease
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靶点ALDH
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受体ALDH
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研究领域——
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适应症——
化学信息
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CAS Number1477-57-2
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分子量366.11
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分子式C12H20Cl4N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (273.14 mM)
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SMILESC(CCCCNC(=O)C(Cl)Cl)CCCNC(=O)C(Cl)Cl
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化学全称N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Amory JK, et al. J Androl. 2011 Jan-Feb;32(1):111-9.
2. Paik J, et al. J Biol Chem. 2014 May 23;289(21):15104-17.
