Vinpocetine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vinpocetine 是环 GMP 磷酸二酯酶 (PDE) 的选择性抑制剂。

Vinpocetine is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).(In Vitro):Vinpocetine (5-50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced NF-κB-dependent transcriptional activity in a dose-dependent manner with an approximate IC50 value of 25 μM. Vinpocetine do not have a significant effect on cell viability.Vinpocetine (50 μM; 7 hours; VSMCs, HUVECs, A549 cells and RAW264.7 cells) potently inhibits TNF-α-induced up-regulation of TNF-α, IL-1β, IL-8, MCP-1, VCAM-1, ICAM-1and MIP-2 transcripts in several cell types.(In Vivo):Vinpocetine (2.5-10 mg/kg; intraperitoneal injection; C57BL/6 mice) potently inhibits TNF-α- or LPS-induced up-regulation of proinflammatory mediators, including TNF-α, IL-1β, and MIP-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-α- or LPS-induced lung inflammation.

RT-PCR Cell Line:VSMCs, HUVECs, A549 cells and RAW264.7 cells Concentration:50 μM Incubation Time:7 hours Result:Inhibited TNF-α-induced up-regulation of TNF-α, IL-1β, IL-8, MCP-1, VCAM-1, ICAM-1and MIP-2 transcripts in several cell types.

Animal Model:C57BL/6 mice (8 weeks of age)Dosage:2.5 mg/kg, 5 mg/kg, and 10 mg/kg Administration:Intraperitoneal injection Result:Inhibited TNF-α- or LPS-induced up-regulation of proinflammatory mediators, including TNF-α, IL-1β, and MIP-2, and decreased interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-α- or LPS-induced lung inflammation.

Apovincaminic Acid ethyl ester | AY 27255 | RGH-4405

Apoptosis

NF-κB

NF-κB| PDE| Sodium Channel

Cardiovascular Disease

——

42971-09-5

350.45

C22H26N2O2

>98% (HPLC)

Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

O=C(C1=C[C@@](CCC2)(CC)[C@]3([H])N2CCC4=C3N1C5=C4C=CC=C5)OCC

ethyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

(-20℃)

With Ice Pack

≥ 2 years