Verdiperstat
CAS No. 890655-80-8
Verdiperstat ( AZD-3241 )
产品货号. M16430 CAS No. 890655-80-8
Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥365 | 有现货 |
|
5MG | ¥583 | 有现货 |
|
10MG | ¥988 | 有现货 |
|
25MG | ¥1798 | 有现货 |
|
50MG | ¥2989 | 有现货 |
|
100MG | ¥4625 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Verdiperstat
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
-
产品描述Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued
-
同义词AZD-3241
-
通路Others
-
靶点Other Targets
-
受体Other Targets
-
研究领域Neurological Disease
-
适应症Spinal Muscular Atrophy(SMA)
化学信息
-
CAS Number890655-80-8
-
分子量253.32
-
分子式C11H15N3O2S
-
纯度>98% (HPLC)
-
溶解度DMSO : 150 mg/mL 592.14 mM
-
SMILESO=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
-
化学全称1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.
2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.
2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.
产品手册
关联产品
-
Oleuroside
Oleuroside can protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.
-
Methyl nomilinate
Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro.
-
Lumefantrine
Lumefantrine (or benflumetol) is an antimalarial drug. It is only used incombination with artemether.