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Verdiperstat

CAS No. 890655-80-8

Verdiperstat ( AZD-3241 )

产品货号. M16430 CAS No. 890655-80-8

Verdiperstat (AZD-3241) 是一种有效、选择性、可逆、口服活性髓过氧化物酶 (MPO) 抑制剂,IC50 为 630 nM,选择性是甲状腺过氧化物酶 (TPO) 的 14 倍以上。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥365 有现货
5MG ¥583 有现货
10MG ¥988 有现货
25MG ¥1798 有现货
50MG ¥2989 有现货
100MG ¥4625 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Verdiperstat
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Verdiperstat (AZD-3241) 是一种有效、选择性、可逆、口服活性髓过氧化物酶 (MPO) 抑制剂,IC50 为 630 nM,选择性是甲状腺过氧化物酶 (TPO) 的 14 倍以上。
  • 产品描述
    Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued(In Vitro):Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.
  • 体外实验
    Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.
  • 体内实验
    ——
  • 同义词
    AZD-3241
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Other Targets
  • 研究领域
    Neurological Disease
  • 适应症
    Spinal Muscular Atrophy(SMA)

化学信息

  • CAS Number
    890655-80-8
  • 分子量
    253.32
  • 分子式
    C11H15N3O2S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 150 mg/mL 592.14 mM
  • SMILES
    O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
  • 化学全称
    1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700. 2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.
产品手册
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