
Verdiperstat
CAS No. 890655-80-8
Verdiperstat ( AZD-3241 )
产品货号. M16430 CAS No. 890655-80-8
Verdiperstat (AZD-3241) 是一种有效、选择性、可逆、口服活性髓过氧化物酶 (MPO) 抑制剂,IC50 为 630 nM,选择性是甲状腺过氧化物酶 (TPO) 的 14 倍以上。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥365 | 有现货 |
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5MG | ¥583 | 有现货 |
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10MG | ¥988 | 有现货 |
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25MG | ¥1798 | 有现货 |
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50MG | ¥2989 | 有现货 |
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100MG | ¥4625 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Verdiperstat
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Verdiperstat (AZD-3241) 是一种有效、选择性、可逆、口服活性髓过氧化物酶 (MPO) 抑制剂,IC50 为 630 nM,选择性是甲状腺过氧化物酶 (TPO) 的 14 倍以上。
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产品描述Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued(In Vitro):Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.
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体外实验Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation.
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体内实验——
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同义词AZD-3241
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Neurological Disease
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适应症Spinal Muscular Atrophy(SMA)
化学信息
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CAS Number890655-80-8
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分子量253.32
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分子式C11H15N3O2S
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纯度>98% (HPLC)
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溶解度DMSO : 150 mg/mL 592.14 mM
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SMILESO=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
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化学全称1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.
2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.
产品手册




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