Verdiperstat ( AZD-3241 )

产品货号. M16430 CAS No. 890655-80-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Verdiperstat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO).
产品描述

Verdiperstat (AZD-3241) is a potent, selective, reversible, orally active myeloperoxidase (MPO) inhibitor with IC50 of 630 nM, >14-fold selectivity over thyroid peroxidase (TPO); inhibits PMA stimulate neutrophils and zymosan stimulated whole blood with IC50 of 80 nM, efficiently inhibits MPO activity in vivo during acute peritonitis in rats and has consistently shown neuroprotective efficacy in MPTP-lesioned mice, a model of Parkinson’s Disease; also demonstrates significant neuroprotection in MSA mouse model.Spinal Muscular Atrophy (SMA) Phase 2 Discontinued
同义词

AZD-3241
通路

Others
靶点

Other Targets
受体

Other Targets
研究领域

Neurological Disease
适应症

Spinal Muscular Atrophy(SMA)

CAS Number

890655-80-8
分子量

253.32
分子式

C11H15N3O2S
纯度

>98% (HPLC)
溶解度

DMSO : 150 mg/mL 592.14 mM
SMILES

O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S
化学全称

1-[2-(propan-2-yloxy)ethyl]-2-sulfanylidene-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

1. Jucaite A, et al. Brain. 2015 Sep;138(Pt 9):2687-700.
2. Kaindlstorfer C, et al. Neurotox Res. 2015 Oct;28(3):185-94.

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