
Vercirnon
CAS No. 698394-73-9
Vercirnon ( GSK-1605786 | CCX282-B | Traficet-EN )
产品货号. M24714 CAS No. 698394-73-9
Vercirnon 是一种选择性且有效的 CCR9 拮抗剂 (IC50: 10 nM)。它还用于炎症性肠病的研究。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥2203 | 有现货 |
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10MG | ¥3467 | 有现货 |
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25MG | ¥5800 | 有现货 |
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50MG | ¥7995 | 有现货 |
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100MG | ¥11097 | 有现货 |
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500MG | ¥22113 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Vercirnon
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Vercirnon 是一种选择性且有效的 CCR9 拮抗剂 (IC50: 10 nM)。它还用于炎症性肠病的研究。
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产品描述Vercirnon is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
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体外实验——
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体内实验Animal Model:C57BL/6 mice (TNFΔARE Mouse Model of Terminal Ileitis)Dosage:10, 50 mg/kg Administration:Subcutaneous; twice per day; starting at 2 weeks of age until 12 weeks of age Result:Resulted in complete protection from the severe inflammation associated with TNF- overexpression at 50 mg/kg. A similar protective effect was also noted with a lower dose.
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同义词GSK-1605786 | CCX282-B | Traficet-EN
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通路Others
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靶点Other Targets
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受体CCR9
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研究领域——
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适应症——
化学信息
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CAS Number698394-73-9
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分子量444.93
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分子式C22H21ClN2O4S
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纯度>98% (HPLC)
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溶解度DMSO : 22.25 mg/mL (50 mM)
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SMILESCC(C)(C)c(cc1)ccc1S(Nc(ccc(Cl)c1)c1C(c(cc1)cc[n+]1[O-])=O)(=O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Walters MJ, et al. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease. J Pharmacol Exp Ther. 2010 Oct;335(1):61-9.
产品手册




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