
Venlafaxine
CAS No. 93413-69-5
Venlafaxine ( Wy 45030 )
产品货号. M22585 CAS No. 93413-69-5
Venlafaxine 是一种芳基烷醇胺血清素-去甲肾上腺素再摄取抑制剂 (SNRI),用于治疗严重的广泛性焦虑症 (GAD)、抑郁症 (MDD)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥324 | 有现货 |
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25MG | ¥624 | 有现货 |
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50MG | ¥940 | 有现货 |
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100MG | ¥1401 | 有现货 |
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200MG | ¥2122 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Venlafaxine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Venlafaxine 是一种芳基烷醇胺血清素-去甲肾上腺素再摄取抑制剂 (SNRI),用于治疗严重的广泛性焦虑症 (GAD)、抑郁症 (MDD)。
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产品描述Venlafaxine, an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.
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体外实验Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM.Venlafaxine inhibits ex vivo binding to rat 5-HT transporters and NE transporters with ED50 values of 2 and 54 mg/kg, respectively.
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体内实验Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA. Animal Model:Male Sprague-Dawley rats weighing 180-230 gramsDosage:10, 30, 100 mg/kg Administration:IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)Result:Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED50 values of 12 and 94 mg/kg, respectively.
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同义词Wy 45030
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通路Others
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靶点Other Targets
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受体serotonin-norepinephrine reuptake
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研究领域nervous system
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适应症Panic Disorder
化学信息
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CAS Number93413-69-5
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分子量277.4
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分子式C17H27NO2
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纯度>98% (HPLC)
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溶解度DMSO:52 mg/mL (187.45mM)
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SMILESCOc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Singh J . Venlafaxine: more dangerous than most "selective" serotonergic antidepressants.[J]. prescrire international, 2016, 25(170):96.
产品手册




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