VUT-MK142

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.VUT-MK142 was identified as the most promising candidate with respect to cardiomyogenic activity.?

VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.VUT-MK142 was identified as the most promising candidate with respect to cardiomyogenic activity.?Treatment using this novel agent induced the strongest up-regulation of expression of the cardiac marker ANF in both P19 embryonic carcinoma cells and C2C12 skeletal myoblasts.?The activity of VUT-MK142 on this marker superseded CgC;?moreover, the novel compound significantly up-regulated the expression of other cardiac markers, and promoted the development of beating cardiomyocytes from cardiovascular progenitor cells.

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Others

Other Targets

Others

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1313491-22-3

298.4

C17H22N4O

>98% (HPLC)

DMSO:25 mg/mL (83.79 mM; Need ultrasonic)

COC1=CC=C(NC2=CC(NC3CCCCC3)=NC=N2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years