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VUT-MK142

CAS No. 1313491-22-3

VUT-MK142 ( —— )

产品货号. M22884 CAS No. 1313491-22-3

VUT-MK142是一种新的心肌生成小分子,可促进心脏前中胚层分化为心肌细胞,可能有助于干细胞分化为心肌细胞以进行心脏修复。VUT-MK142被认为是最有前途的心肌生成活性候选者。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥956 有现货
5MG ¥1596 有现货
10MG ¥2406 有现货
25MG ¥4836 有现货
50MG ¥6707 有现货
100MG ¥9315 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    VUT-MK142
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    VUT-MK142是一种新的心肌生成小分子,可促进心脏前中胚层分化为心肌细胞,可能有助于干细胞分化为心肌细胞以进行心脏修复。VUT-MK142被认为是最有前途的心肌生成活性候选者。
  • 产品描述
    VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.VUT-MK142 was identified as the most promising candidate with respect to cardiomyogenic activity.?Treatment using this novel agent induced the strongest up-regulation of expression of the cardiac marker ANF in both P19 embryonic carcinoma cells and C2C12 skeletal myoblasts.?The activity of VUT-MK142 on this marker superseded CgC;?moreover, the novel compound significantly up-regulated the expression of other cardiac markers, and promoted the development of beating cardiomyocytes from cardiovascular progenitor cells.
  • 体外实验
    VUT-MK142 possesses promising cardiomyogenic effects on various cell types. VUT-MK142 shows a remarkable effect on both P19 and C2C12 cells. Compared to CgC, VUT-MK142-treatment leads to a markedly stronger up-regulation of the expression of ANF.VUT-MK142 (1 μM, 7 day treatment) significantly (p < 0.05) increases the luciferase signal by 3.1 ± 0.3 luciferase (n = 5)-fold in P19 cells.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1313491-22-3
  • 分子量
    298.4
  • 分子式
    C17H22N4O
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:25 mg/mL (83.79 mM; Need ultrasonic)
  • SMILES
    COC1=CC=C(NC2=CC(NC3CCCCC3)=NC=N2)C=C1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Moumita Koley, et al. VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes. Medchemcomm. 2013 Aug 1;4(8):1189-1195.
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