
VUT-MK142
CAS No. 1313491-22-3
VUT-MK142 ( —— )
产品货号. M22884 CAS No. 1313491-22-3
VUT-MK142是一种新的心肌生成小分子,可促进心脏前中胚层分化为心肌细胞,可能有助于干细胞分化为心肌细胞以进行心脏修复。VUT-MK142被认为是最有前途的心肌生成活性候选者。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥956 | 有现货 |
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5MG | ¥1596 | 有现货 |
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10MG | ¥2406 | 有现货 |
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25MG | ¥4836 | 有现货 |
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50MG | ¥6707 | 有现货 |
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100MG | ¥9315 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称VUT-MK142
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述VUT-MK142是一种新的心肌生成小分子,可促进心脏前中胚层分化为心肌细胞,可能有助于干细胞分化为心肌细胞以进行心脏修复。VUT-MK142被认为是最有前途的心肌生成活性候选者。
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产品描述VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.VUT-MK142 was identified as the most promising candidate with respect to cardiomyogenic activity.?Treatment using this novel agent induced the strongest up-regulation of expression of the cardiac marker ANF in both P19 embryonic carcinoma cells and C2C12 skeletal myoblasts.?The activity of VUT-MK142 on this marker superseded CgC;?moreover, the novel compound significantly up-regulated the expression of other cardiac markers, and promoted the development of beating cardiomyocytes from cardiovascular progenitor cells.
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体外实验VUT-MK142 possesses promising cardiomyogenic effects on various cell types. VUT-MK142 shows a remarkable effect on both P19 and C2C12 cells. Compared to CgC, VUT-MK142-treatment leads to a markedly stronger up-regulation of the expression of ANF.VUT-MK142 (1 μM, 7 day treatment) significantly (p < 0.05) increases the luciferase signal by 3.1 ± 0.3 luciferase (n = 5)-fold in P19 cells.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1313491-22-3
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分子量298.4
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分子式C17H22N4O
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纯度>98% (HPLC)
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溶解度DMSO:25 mg/mL (83.79 mM; Need ultrasonic)
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SMILESCOC1=CC=C(NC2=CC(NC3CCCCC3)=NC=N2)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Moumita Koley, et al. VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes. Medchemcomm. 2013 Aug 1;4(8):1189-1195.
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