VS-5584

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VS-5584 是一种泛 PI3K/mTOR 激酶抑制剂。

VS-5584, also known as SB2343, is a potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy.

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VS5584 | VS 5584 | VS5584 | SB2343

Immunology/Inflammation

Amino Acids and Derivatives

mTOR| PI3Kα| PI3Kβ| PI3Kγ| PI3Kδ

Cancer

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1246560-33-7

354.41

C17H22N8O

>98% (HPLC)

DMSO : 33.33 mg/mL. 94.04 mM;

CC(C)n1c(C)nc2c1nc(nc2c1cnc(N)nc1)N1CCOCC1

5-(9-isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

(-20℃)

With Ice Pack

≥ 2 years