
VK-28
CAS No. 312611-92-0
VK-28 ( —— )
产品货号. M28982 CAS No. 312611-92-0
VK-28 是一种具有神经保护作用的脑渗透性铁螯合剂。 VK-28 抑制基础以及铁诱导的线粒体脂质过氧化。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3540 | 有现货 |
![]() ![]() |
10MG | ¥5233 | 有现货 |
![]() ![]() |
25MG | ¥7995 | 有现货 |
![]() ![]() |
50MG | ¥11178 | 有现货 |
![]() ![]() |
100MG | ¥15066 | 有现货 |
![]() ![]() |
500MG | ¥30132 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称VK-28
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述VK-28 是一种具有神经保护作用的脑渗透性铁螯合剂。 VK-28 抑制基础以及铁诱导的线粒体脂质过氧化。
-
产品描述VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.(In Vitro):VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier.(In Vivo):VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number312611-92-0
-
分子量287.36
-
分子式C16H21N3O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESOCCN1CCN(CC2=CC=C(O)C3=NC=CC=C23)CC1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Fedosejevs ET, Feil R, Lunn JE, Plaxton WC. The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans. FEBS Lett. 2018 Aug;592(15):2525-2532.
产品手册




关联产品
-
beta-Escin
β-七叶皂苷是从七叶树 (Aesculus hippocastanum) 种子中分离出来的三萜皂苷的天然混合物。
-
4-hydroxy-3-methylbe...
4-羟基-3-甲基苯甲酸是在健康人群的尿液样本中发现的一种正常有机酸。
-
Benzamide
Benzamide 是一种聚(ADP-核糖)聚合酶抑制剂,是苯甲酸的衍生物。