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VK-28
CAS No. 312611-92-0
VK-28 ( —— )
产品货号. M28982 CAS No. 312611-92-0
VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3540 | 有现货 |
|
| 10MG | ￥5233 | 有现货 |
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| 25MG | ￥7995 | 有现货 |
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| 50MG | ￥11178 | 有现货 |
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| 100MG | ￥15066 | 有现货 |
|
| 500MG | ￥30132 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称VK-28
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.
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产品描述VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.(In Vitro):VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier.(In Vivo):VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number312611-92-0
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分子量287.4
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分子式C16H21N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESOCCN1CCN(CC2=CC=C(O)C3=NC=CC=C23)CC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Fedosejevs ET, Feil R, Lunn JE, Plaxton WC. The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans. FEBS Lett. 2018 Aug;592(15):2525-2532.
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