VK-28 ( —— )

产品货号. M28982 CAS No. 312611-92-0

VK-28 是一种具有神经保护作用的脑渗透性铁螯合剂。 VK-28 抑制基础以及铁诱导的线粒体脂质过氧化。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥3540	有现货
10MG	￥5233	有现货
25MG	￥7995	有现货
50MG	￥11178	有现货
100MG	￥15066	有现货
500MG	￥30132	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

VK-28
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

VK-28 是一种具有神经保护作用的脑渗透性铁螯合剂。 VK-28 抑制基础以及铁诱导的线粒体脂质过氧化。
产品描述

VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.(In Vitro):VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier.(In Vivo):VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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化学信息

CAS Number

312611-92-0
分子量

287.36
分子式

C16H21N3O2
纯度

>98% (HPLC)
溶解度

——
SMILES

OCCN1CCN(CC2=CC=C(O)C3=NC=CC=C23)CC1
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Fedosejevs ET, Feil R, Lunn JE, Plaxton WC. The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans. FEBS Lett. 2018 Aug;592(15):2525-2532.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册