VH-032

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VH-032（VHL 配体 1）是 PROTAC 的 VHL 配体，也是 VHL/HIF-1α 相互作用的有效小分子抑制剂，Kd 为 185 nM。

VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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VHL ligand 1

PROTACs

E3 Ligase Ligand

E3 Ligase Ligand

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1448188-62-2

472.604

C24H32N4O4S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (211.60 mM)

CC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O

(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years