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VB-82252
CAS No. 2170004-34-7
VB-82252 ( VB82252 )
产品货号. M13463 CAS No. 2170004-34-7
VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称VB-82252
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM).
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产品描述VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM); protects CHO-K1 cells against challenge with purified TcdA (IC50 = 5.0 uM) or TcdB (IC50=0.25 uM); prevents inflammation in murine intrarectal toxin challenge model, reduces weight loss and gut inflammation during acute disease in murine model of recurrent Clostridium difficile infection (CDI), demonstrates efficacy similar to that of vancomycin.
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同义词VB82252
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域——
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适应症——
化学信息
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CAS Number2170004-34-7
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分子量614.41
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分子式C29H20Cl2F3N5O3
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(R)-2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Stroke IL, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00107-18.
产品手册
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