Uprosertib ( GSK2141795, GSK 795, Uprosertib )

产品货号. M17123 CAS No. 1047634-65-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Uprosertib
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Uprosertib (GSK2141795) 是一种选择性、ATP 竞争性、口服生物可利用的 Akt 抑制剂，对 Akt 1、2 和 3 的 IC50 值分别为 180 nM、328 nM 和 38 nM。
产品描述

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
体外实验

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体内实验

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同义词

GSK2141795, GSK 795, Uprosertib
通路

Others
靶点

Other Targets
受体

Akt1| Akt2| Akt3
研究领域

Cancer
适应症

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CAS Number

1047634-65-0
分子量

429.25
分子式

C18H16Cl2F2N4O2
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL
SMILES

Cn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl
化学全称

N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide

1.Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.

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