Uprosertib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Uprosertib (GSK2141795) 是一种选择性、ATP 竞争性、口服生物可利用的 Akt 抑制剂，对 Akt 1、2 和 3 的 IC50 值分别为 180 nM、328 nM 和 38 nM。

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

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GSK2141795, GSK 795, Uprosertib

Others

Other Targets

Akt1| Akt2| Akt3

Cancer

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1047634-65-0

429.25

C18H16Cl2F2N4O2

>98% (HPLC)

DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL

Cn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl

N-((S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years