USP25 and 28 inhibitor AZ-2 ( USP25/28 inhibitor AZ2 )

产品货号. M13456 CAS No. 2165322-95-0

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

USP25 and 28 inhibitor AZ-2
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
产品描述

USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
同义词

USP25/28 inhibitor AZ2
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

——
适应症

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1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.

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USP25 and 28 inhibit...

USP25 and 28 inhibitor AZ-2 is apotent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.