UNC0379 ( UNC 0379 | UNC-0379 )

产品货号. M12379 CAS No. 1620401-82-2

UNC0379 是赖氨酸甲基转移酶 SETD8 的选择性底物竞争性抑制剂，IC50 为 7.3 uM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥381	有现货
10MG	￥648	有现货
25MG	￥1183	有现货
50MG	￥2001	有现货
100MG	￥3013	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

UNC0379
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

UNC0379 是赖氨酸甲基转移酶 SETD8 的选择性底物竞争性抑制剂，IC50 为 7.3 uM。
产品描述

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM); causes neuroblastoma (NB) cell growth inhibition which is p53 dependent, reduces levels of p53K382me1 modification in xenografts.
体外实验

UNC0379 (1-10 μM, 9 days) inhibits HGSOC cells proliferation.?UNC0379 (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells.UNC0379 (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation. Cell Viability Assay Cell Line:JHOS2, JHOS3, JHOS4, OVCAR3, OVCAHO, OVKATE, KURAMOCHI, TYKnu Concentration:1-10 μM Incubation Time:9 days Result:Inhibited HGSOC cells proliferation with IC50s ranging from 0.39 to 3.20 μM.Cell Cycle Analysis Cell Line:JHOS3, OVCAR3 Concentration:10 μM Incubation Time:96 hResult:Arrested cells in sub-G1 phase.
体内实验

UNC0379 (intratracheal administration, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse. Animal Model:Bleomycin (BLM)-induced lung fibrosis mouse modelDosage:1 mg/kg/day Administration:Intratracheal administration, on day7, 8, and 9.Result:Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.
同义词

UNC 0379 | UNC-0379
通路

Chromatin/Epigenetic
靶点

HMTase
受体

SETD8
研究领域

Other Indications
适应症

——

化学信息

CAS Number

1620401-82-2
分子量

413.5563
分子式

C23H35N5O2
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

COC1=C(OC)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1
化学全称

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33. 2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898. 3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册