
UM-171
CAS No. 1448724-09-1
UM-171 ( UM171 )
产品货号. M11925 CAS No. 1448724-09-1
UM-171 是人类造血干细胞自我更新的有效激动剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称UM-171
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述UM-171 是人类造血干细胞自我更新的有效激动剂。
-
产品描述UM-171 is a potent agonist of human hematopoietic stem cell self-renewal, shows 10 to 20 times more potent than UM729 with effective concentrations of 17 to 19 nM; enables a robust ex vivo expansion of human CB cells with functionally validated long-term in vivo repopulating capability.Blood Cancer Phase 2 Clinical.
-
体外实验UM171 (50-100 nM) significantly increases CD34+ CD43+ and CD34+ CD45+ hematopoietic progenitors. UM171 enhances the derivation of hematopoietic cells at multiple developmental steps. UM171 enhances de novo generation of hematopoietic progenitor cells from hPSCs at multiple phases during hematopoietic differentiation in vitro. UM171 shows no effect on erythroid development, but inhibits erythroid maturation. UM171 treatment enhances the engraftment potential of CD34+ macaque cells by threefold. UM171 attenuates cell differentiation and promotes ex vivo expansion of primitive human hematopoietic cells, and promotes expansion of LT-HSCs. UM171 treatment results in down-regulation of AhR target genes such as CYP1B1, CYP1A1, and AhRR.
-
体内实验——
-
同义词UM171
-
通路Others
-
靶点Other Targets
-
受体Other Targets
-
研究领域Cancer
-
适应症Blood cancer
化学信息
-
CAS Number1448724-09-1
-
分子量487.94
-
分子式C25H27N9
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : ≥ 75 mg/mL (165.37 mM)
-
SMILESN[C@H]1CC[C@H](NC2=C3C(NC4=C3C=CC(C5=NN(C)N=N5)=C4)=NC(CC6=CC=CC=C6)=N2)CC1
-
化学全称(1r,4r)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Fares I, et al. Science. 2014 Sep 19;345(6203):1509-12.
2. Li X, et al. Stem Cell Res. 2017 May;21:32-39.
3. Zonari E, et al. Stem Cell Reports. 2017 Apr 11;8(4):977-990.
产品手册




关联产品
-
2-Carboxybenzaldehyd...
The major peak of 2-Carboxybenzaldehyde reductase activity in human liver co-purifies with hAFAR protein. Sulphydryl substances and some proteins play important roles in preserving the molecular and catalytic properties of 2-Carboxybenzaldehyde reductase.
-
Irganox 1010
Irganox 1010 是一种抗氧化剂。
-
Tetrahydrothiophen-3...
四氢噻吩-3-酮可用作食品香料。