UK-5099

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UK 5099 is a specific and potent inhibitor of MPC carrier activity. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM).

UK-5099 is a specific and potent mitochondrial pyruvate carrier blocker (MCK blocker). The UK5099 treated cells showed significantly higher proportion of side population (SP) fraction and expressed higher levels of stemness markers Oct3/4 and Nanog. Chemosensitivity examinations revealed that the UK5099 treated cells became more resistant to chemotherapy compared to the non-treated cells. MPC blocker (UK5099) application may be an ideal model for Warburg effect studies

UK-5099, UK 5099, UK5099

Others

Other Targets

MPC

Cancer

——

56396-35-1

288.3

C18H12N2O2

98%

DMSO : ≥ 50 mg/mL. 173.43 mM; H2O : < 0.1 mg/mL

OC(=O)C(=Cc1cn(-c2ccccc2)c2ccccc12)C#N

2-cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

(-20℃)

With Ice Pack

≥ 2 years