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UK-396082
CAS No. 400044-47-5
UK-396082 ( UK 396,082;UK396082 )
产品货号. M14370 CAS No. 400044-47-5
UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥8667 | 有现货 |
|
| 50MG | ￥17658 | 有现货 |
|
| 100MG | ￥22680 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称UK-396082
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM.
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产品描述UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10 nM; displays excellent selectivity over plasma carboxypeptidase N (>1,000-fold); exhibits antithrombotic efficacy in a rabbit model of venous thrombosis, yet has no effect on surgical bleeding in the rabbit; possesses excellent preclinical and clinical pharmacokinetic profile, and shows potential for the treatment of thrombosis and other fibrin-dependent diseases in humans.Thrombosis Phase 1 Discontinued
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同义词UK 396,082;UK396082
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通路Others
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靶点Other Targets
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受体Other Targets
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研究领域Cardiovascular Disease
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适应症Thrombosis
化学信息
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CAS Number400044-47-5
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分子量239.32
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分子式C12H21N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCCCN1C=C(N=C1)C[C@H](CCCN)C(=O)O
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化学全称(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bunnage ME, et al. J Med Chem. 2007 Nov 29;50(24):6095-103.
2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24;32(5):277-87.
3. Bridge K, et al. PLoS One. 2017 May 4;12(5):e0177117.
2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24;32(5):277-87.
3. Bridge K, et al. PLoS One. 2017 May 4;12(5):e0177117.
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