Tulrampator

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tulrampator (S 47445;CX 1632) 是一种新型有效、选择性、AMPA 受体 (AMPAR) 正变构调节剂，对于不同 AMPA 受体亚型的 EC50 为 2.5-5.4 uM。

Tulrampator (S 47445;CX 1632) is a novel potent, selective, positive allosteric modulator of AMPA receptor (AMPAR) with EC50 of 2.5-5.4 uM for different AMPA receptors subtypes (GluA1/2/4 flip and flop variants); exhibits procognitive and potential neuroprotective properties in vivo.Alzheimer Disease Phase 2 Clinical.

——

Animal Model:chronic corticosterone administration (CORT) mice Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg Administration:Oral gavage (p.o.)Result:Reversed anxio-depressive phenotype in a neurogenesis-dependent task.Decreased the corticosterone-induced increase in emotionality.Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model.Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus.Animal Model:bilateral olfactory bulbectomy mice model Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Significantly reverted OB-induced hyperactivity after 28 days. Increased open field central activity in OB mice.

S 47445 | CX 1632

Membrane Transporter/Ion Channel

iGluR

iGluR

Neurological Disease

Alzheimer Disease

1038984-31-4

380.379

C20H17FN4O3

>98% (HPLC)

DMSO : 21.67 mg/mL56.97 mM;

O=C1N(CCC2=CC=CC(F)=C2)N=NC3=CC4=C(OCN(C5CC5)C4=O)C=C13

8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

(-20℃)

With Ice Pack

≥ 2 years