Tubercidin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

从结核链霉菌中分离出来的抗生素和腺苷类似物，具有潜在的抗肿瘤活性。

An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity; incorporates into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis; also exhibits antifungal and antiviral activities.(In Vitro):Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin were 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively.(In Vivo):Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival.

Cell Cytotoxicity Assay Cell Line:Human bone marrow progenitor cells Concentration:0-10 nM Incubation Time:14 days Result:Had a dose-dependent inhibitory effect for CFU-GM and BFU-E.

Animal Model:Female CD1 miceDosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg; 10 days Result:Protectedthe mice from the lethality of tubercidin.

Sparsomycin A | 7-Deazaadenosine | NSC-56408

GPCR/G Protein

Antibacterial

DNA/RNA Synthesis

Infection

——

69-33-0

266.2533

C11H14N4O4

>98% (HPLC)

DMSO: ≥ 30 mg/mL

NC1=NC=NC2=C1C=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-

(-20℃)

With Ice Pack

≥ 2 years