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Tricetin

CAS No. 520-31-0

Tricetin ( —— )

产品货号. M32124 CAS No. 520-31-0

Tricetin is a flavonoid isolated from pomegranate.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
10MG ¥1154 有现货
50MG 获取报价 有现货
100MG 获取报价 有现货

生物学信息

  • 产品名称
    Tricetin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Tricetin is a flavonoid isolated from pomegranate.
  • 产品描述
    Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by activating the Nrf2/HO-1 signaling pathway and blocking mitochondria-dependent apoptotic pathways.Tricetin Inhibits migration and expression of the indicator protease progerin-1 (PS-1) in nasopharyngeal carcinoma through the Akt/GSK-1β pathway.Tricetin inhibits endothelial inflammation induced by oxidized LDL mediated by Egr-1, and protects rat chondrocytes from IL-1β-induced inflammation and apoptosis.Tricetin is an inhibitor of endothelial inflammation induced by oxidized LDL mediated by Egr-1 and protects against IL-1β-induced inflammation and apoptosis.
  • 体外实验
    Tricetin is mainly found in natural plants such as?Ginkgo biloba?L.,?Carica papaya?L. and?Murraya exotica?L.?Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of?C. elegans. Tricetin has?cytostatic?properties and anti-metastatic activity of various?solid tumors.Pretreatment?with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200?μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis.Tricetin (80?μM; for 1, 2 and 4?h) markedly decreased the expressions of p-JNK and p-p38. Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:20, 40, and 80 μM Incubation Time:Pretreatment?for 4?h followed by 6-OHDA (200?μM) for 24?h Result:Significantly increased 6-OHDA-induced SH-SY5Y cells viability.Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:80?μM Incubation Time:1, 2 and 4?h Result:Markedly decreased the expressions of p-JNK and p-p38.?
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    520-31-0
  • 分子量
    302.2
  • 分子式
    C15H10O7
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    ——
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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