Tricetin
CAS No. 520-31-0
Tricetin ( —— )
产品货号. M32124 CAS No. 520-31-0
Tricetin is a flavonoid isolated from pomegranate.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥1154 | 有现货 |
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50MG | 获取报价 | 有现货 |
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100MG | 获取报价 | 有现货 |
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生物学信息
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产品名称Tricetin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Tricetin is a flavonoid isolated from pomegranate.
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产品描述Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by activating the Nrf2/HO-1 signaling pathway and blocking mitochondria-dependent apoptotic pathways.Tricetin Inhibits migration and expression of the indicator protease progerin-1 (PS-1) in nasopharyngeal carcinoma through the Akt/GSK-1β pathway.Tricetin inhibits endothelial inflammation induced by oxidized LDL mediated by Egr-1, and protects rat chondrocytes from IL-1β-induced inflammation and apoptosis.Tricetin is an inhibitor of endothelial inflammation induced by oxidized LDL mediated by Egr-1 and protects against IL-1β-induced inflammation and apoptosis.
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体外实验Tricetin is mainly found in natural plants such as?Ginkgo biloba?L.,?Carica papaya?L. and?Murraya exotica?L.?Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of?C. elegans. Tricetin has?cytostatic?properties and anti-metastatic activity of various?solid tumors.Pretreatment?with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200?μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis.Tricetin (80?μM; for 1, 2 and 4?h) markedly decreased the expressions of p-JNK and p-p38. Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:20, 40, and 80 μM Incubation Time:Pretreatment?for 4?h followed by 6-OHDA (200?μM) for 24?h Result:Significantly increased 6-OHDA-induced SH-SY5Y cells viability.Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:80?μM Incubation Time:1, 2 and 4?h Result:Markedly decreased the expressions of p-JNK and p-p38.?
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number520-31-0
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分子量302.2
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分子式C15H10O7
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
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