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Toyocamycin

CAS No. 606-58-6

Toyocamycin ( Vengicide )

产品货号. M22947 CAS No. 606-58-6

Toyocamycin 是放线菌产生的腺苷类似物,作为 XBP1 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 裂解 (IC50: 80 nM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥316 有现货
10MG ¥478 有现货
25MG ¥932 有现货
50MG ¥1725 有现货
100MG ¥3013 有现货
500MG ¥7039 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Toyocamycin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Toyocamycin 是放线菌产生的腺苷类似物,作为 XBP1 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 裂解 (IC50: 80 nM)。
  • 产品描述
    Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
  • 体外实验
    Western Blot Analysis Cell Line:HeLa, HEK293 Concentration:0, 0.03, 0.1, 0.3 μM Incubation Time:4 hours Result:Suppressed neither tunicamycin-induced ATF6 nor PERK activation.Inhibited IRE1α-induced XBP1 mRNA cleavage without affecting IRE1α phosphorylation on Ser724.Western Blot Analysis Cell Line:Human prostate cancer PC-3 cells Concentration:60 nM Incubation Time:12, 24, 36, 48 hours Result:Suppressed the phosphorylation level of AKA, while decreasing the phosphorylation level of ERK and p38. Cell Viability Assay Cell Line:PC-3 and RWPE-1 cells Concentration:0, 20, 40, 60, 80, 100 nM Incubation Time:24 or 48 hours Result:Inhibted cell viability and induced cell apoptosis by 62%.
  • 体内实验
    Animal Model:SCID mice injected with human multiple myeloma (MM) cellsDosage:0.5 mg/kg, 1.0 mg/kg Administration:Intraperitoneal injection; twice a week; 2 weeks Result:Reduced the tumor volume significantly.Showed enhancing anti-tumor activity represented as smaller tumor volumes when compared with Bortezomib (HY-10227).
  • 同义词
    Vengicide
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    XBP1
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    606-58-6
  • 分子量
    291.26
  • 分子式
    C12H13N5O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:100 mg/mL (343.34 mM; Need ultrasonic)
  • SMILES
    O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79.
产品手册
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