
Toyocamycin
CAS No. 606-58-6
Toyocamycin ( Vengicide )
产品货号. M22947 CAS No. 606-58-6
Toyocamycin 是放线菌产生的腺苷类似物,作为 XBP1 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 裂解 (IC50: 80 nM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥478 | 有现货 |
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25MG | ¥932 | 有现货 |
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50MG | ¥1725 | 有现货 |
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100MG | ¥3013 | 有现货 |
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500MG | ¥7039 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Toyocamycin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Toyocamycin 是放线菌产生的腺苷类似物,作为 XBP1 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 裂解 (IC50: 80 nM)。
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产品描述Toyocamycin is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
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体外实验Western Blot Analysis Cell Line:HeLa, HEK293 Concentration:0, 0.03, 0.1, 0.3 μM Incubation Time:4 hours Result:Suppressed neither tunicamycin-induced ATF6 nor PERK activation.Inhibited IRE1α-induced XBP1 mRNA cleavage without affecting IRE1α phosphorylation on Ser724.Western Blot Analysis Cell Line:Human prostate cancer PC-3 cells Concentration:60 nM Incubation Time:12, 24, 36, 48 hours Result:Suppressed the phosphorylation level of AKA, while decreasing the phosphorylation level of ERK and p38. Cell Viability Assay Cell Line:PC-3 and RWPE-1 cells Concentration:0, 20, 40, 60, 80, 100 nM Incubation Time:24 or 48 hours Result:Inhibted cell viability and induced cell apoptosis by 62%.
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体内实验Animal Model:SCID mice injected with human multiple myeloma (MM) cellsDosage:0.5 mg/kg, 1.0 mg/kg Administration:Intraperitoneal injection; twice a week; 2 weeks Result:Reduced the tumor volume significantly.Showed enhancing anti-tumor activity represented as smaller tumor volumes when compared with Bortezomib (HY-10227).
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同义词Vengicide
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通路Others
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靶点Other Targets
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受体XBP1
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研究领域——
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适应症——
化学信息
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CAS Number606-58-6
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分子量291.26
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分子式C12H13N5O4
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (343.34 mM; Need ultrasonic)
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SMILESO[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79.
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