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Tiopronin

CAS No. 1953-02-2

Tiopronin ( BRN 1859822 | (±)-Tiopronin )

产品货号. M13057 CAS No. 1953-02-2

硫普罗宁(商品名Thiola)是一种处方硫醇化合物,用于控制胱氨酸尿症疾病中胱氨酸沉淀和排泄的速率。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥340 有现货
100MG ¥478 有现货
200MG ¥680 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Tiopronin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    硫普罗宁(商品名Thiola)是一种处方硫醇化合物,用于控制胱氨酸尿症疾病中胱氨酸沉淀和排泄的速率。
  • 产品描述
    Tiopronin (trade name Thiola) is a prescription thiol drug used to control the rate of cystine precipitation and excretion in the disease cystinuria. Due to the rarity of the disorder, tioronin falls under the classification of an orphan drug.(In Vitro):In in vitro Von Hippel-Lindau protein binding assay, the inhibitory effect of Tiopronin (NMPG) on HPH-2 was attenuated by escalating dose of ascorbate but not 2-ketoglutarate, cofactors of the enzyme.(In Vivo):Tiopronin (NMPG) alleviates colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuates expression of pro-inflammatory mediators in the inflamed colon. NMPG induces hypoxia-inducible factor-1α (HIF-1α) in human colon carcinoma cells, leading to elevated secretion of vascular endothelial growth factor (VEGF), a target gene product of HIF-1 involved in ulcer healing of gastrointestinal mucosa. NMPG induces HIF-1α occurred by inhibiting HIF prolyl hydroxylase-2 (HPH-2), an enzyme that plays a major role in negatively regulating HIF-1α protein stability.
  • 体外实验
    In in vitro Von Hippel-Lindau protein binding assay, the inhibitory effect of Tiopronin (NMPG) on HPH-2 was attenuated by escalating dose of ascorbate but not 2-ketoglutarate, cofactors of the enzyme.
  • 体内实验
    Tiopronin (NMPG) alleviates colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuates expression of pro-inflammatory mediators in the inflamed colon. NMPG induces hypoxia-inducible factor-1α (HIF-1α) in human colon carcinoma cells, leading to elevated secretion of vascular endothelial growth factor (VEGF), a target gene product of HIF-1 involved in ulcer healing of gastrointestinal mucosa. NMPG induces HIF-1α occurred by inhibiting HIF prolyl hydroxylase-2 (HPH-2), an enzyme that plays a major role in negatively regulating HIF-1α protein stability.
  • 同义词
    BRN 1859822 | (±)-Tiopronin
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Metabolic Disease
  • 适应症
    ——

化学信息

  • CAS Number
    1953-02-2
  • 分子量
    163.19
  • 分子式
    C5H9NO3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 32 mg/mL (196.09 mM); Water: 32 mg/mL (196.09 mM); DMSO: 32 mg/mL (196.09 mM)
  • SMILES
    O=C(O)CNC(C(S)C)=O
  • 化学全称
    Glycine, N-(2-mercapto-1-oxopropyl)- (9CI)

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Zheng Z, et al. Ren Fail. 2014 Oct;36(9):1455-60.
产品手册
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