
Tiopronin
CAS No. 1953-02-2
Tiopronin ( BRN 1859822 | (±)-Tiopronin )
产品货号. M13057 CAS No. 1953-02-2
硫普罗宁(商品名Thiola)是一种处方硫醇化合物,用于控制胱氨酸尿症疾病中胱氨酸沉淀和排泄的速率。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥340 | 有现货 |
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100MG | ¥478 | 有现货 |
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200MG | ¥680 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Tiopronin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述硫普罗宁(商品名Thiola)是一种处方硫醇化合物,用于控制胱氨酸尿症疾病中胱氨酸沉淀和排泄的速率。
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产品描述Tiopronin (trade name Thiola) is a prescription thiol drug used to control the rate of cystine precipitation and excretion in the disease cystinuria. Due to the rarity of the disorder, tioronin falls under the classification of an orphan drug.(In Vitro):In in vitro Von Hippel-Lindau protein binding assay, the inhibitory effect of Tiopronin (NMPG) on HPH-2 was attenuated by escalating dose of ascorbate but not 2-ketoglutarate, cofactors of the enzyme.(In Vivo):Tiopronin (NMPG) alleviates colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuates expression of pro-inflammatory mediators in the inflamed colon. NMPG induces hypoxia-inducible factor-1α (HIF-1α) in human colon carcinoma cells, leading to elevated secretion of vascular endothelial growth factor (VEGF), a target gene product of HIF-1 involved in ulcer healing of gastrointestinal mucosa. NMPG induces HIF-1α occurred by inhibiting HIF prolyl hydroxylase-2 (HPH-2), an enzyme that plays a major role in negatively regulating HIF-1α protein stability.
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体外实验In in vitro Von Hippel-Lindau protein binding assay, the inhibitory effect of Tiopronin (NMPG) on HPH-2 was attenuated by escalating dose of ascorbate but not 2-ketoglutarate, cofactors of the enzyme.
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体内实验Tiopronin (NMPG) alleviates colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuates expression of pro-inflammatory mediators in the inflamed colon. NMPG induces hypoxia-inducible factor-1α (HIF-1α) in human colon carcinoma cells, leading to elevated secretion of vascular endothelial growth factor (VEGF), a target gene product of HIF-1 involved in ulcer healing of gastrointestinal mucosa. NMPG induces HIF-1α occurred by inhibiting HIF prolyl hydroxylase-2 (HPH-2), an enzyme that plays a major role in negatively regulating HIF-1α protein stability.
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同义词BRN 1859822 | (±)-Tiopronin
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通路Others
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靶点Other Targets
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受体Others
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研究领域Metabolic Disease
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适应症——
化学信息
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CAS Number1953-02-2
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分子量163.19
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分子式C5H9NO3S
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纯度>98% (HPLC)
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溶解度Ethanol: 32 mg/mL (196.09 mM); Water: 32 mg/mL (196.09 mM); DMSO: 32 mg/mL (196.09 mM)
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SMILESO=C(O)CNC(C(S)C)=O
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化学全称Glycine, N-(2-mercapto-1-oxopropyl)- (9CI)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Zheng Z, et al. Ren Fail. 2014 Oct;36(9):1455-60.
产品手册




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