Tilianin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tilianin 是 Dragocephalum Moldavicum L 的黄酮苷。

Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L.

Tilianin (10 μM, 20 μM) reduced secretion of LPS (1 μg/mL)-induced proinflammatory cytokine in RAW264.7 macrophage cell.

Tilianin (10 mg/kg; i.p.) is a potential agent for ameliorating LPS-induced acute lung injury (ALI).Tilianin shows Tmax=10.8 min,Cmax=176.9 nmol/L, AUC0-∞= 17.4 min*μmol/L in mice. Animal Model:C57BL/6 mouse Dosage:10 mg/kg Administration:Intraperitoneal injection Result:Attenuated infiltration of macrophages and histopathological changes and improved inflammation.Animal Model:Male FVB mice (6-10 weeks) Dosage:10 mg/kg (Pharmacokinetic Analysis)Administration:Oral gavage Result:Tmax(10.8 min), Cmax(176.9 nmol/L), AUC0-∞(17.4 min*μmol/L).

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Others

Other Targets

Others

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4291-60-5

446.4

C22H22O10

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (112.01 mM)

COc(cc1)ccc1C(Oc1c2c(O)cc(O[C@@H]([C@@H]([C@H]3O)O)O[C@H](CO)[C@H]3O)c1)=CC2=O

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(-20℃)

With Ice Pack

≥ 2 years