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Thioacetazone

CAS No. 104-06-3

Thioacetazone ( Diazam | Neotibil | Neustab )

产品货号. M21119 CAS No. 104-06-3

硫代乙酰腙是一种缩氨基硫脲,即硫代乙酰腙治疗肺结核。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥389 有现货
5MG ¥648 有现货
10MG ¥786 有现货
25MG ¥1426 有现货
50MG ¥2122 有现货
100MG ¥3151 有现货
200MG ¥4641 有现货
500MG ¥7152 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Thioacetazone
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    硫代乙酰腙是一种缩氨基硫脲,即硫代乙酰腙治疗肺结核。
  • 产品描述
    Thioacetazone is a thiosemicarbazone that?thioacetazone treatment of pulmonary tuberculosis.(In Vitro):Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl.(In Vivo):aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat.
  • 体外实验
    Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl.
  • 体内实验
    The Km and Vmax values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat.
  • 同义词
    Diazam | Neotibil | Neustab
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    others
  • 研究领域
    Infection
  • 适应症
    Mycobacterium Avium-intracellulare Infection

化学信息

  • CAS Number
    104-06-3
  • 分子量
    236.29
  • 分子式
    C10H12N4OS
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (423.21 mM)
  • SMILES
    CC(=O)Nc1ccc(/C=N/NC(N)=S)cc1
  • 化学全称
    Acetamide N-(4-(((aminothioxomethyl)hydrazono)methyl)phenyl)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.K.A.-T.A.a.G.T.S.: Hong. A controlled comparison of thiacetazone (thioacetazone) plus isoniazid with pas plus isoniazid in Hong Kong[J]. tubercle 1968 49(3):243-280.
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