Thiamphenicol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

甲砜霉素是一种抗菌抗生素，是氯霉素的甲基磺酰类似物。

Thiamphenicol is an antimicrobial antibiotic and a methyl-sulfonyl analogue of chloramphenicol.(In Vitro):Thiamphenicol shows a significant post-antibiotic effect (PAE) (0.33 to 2.9h) on all pathogens studied (S. pneumoniae, S. aureus and Escherichia coli) and a powerful bactericidal effect against β-lactamase-positive and -negative H. influenzae. Thiamphenicol MICs for the microorganisms analyzed are: 32 mg/L (S. aureus and E. coli), 2 mg/L (S. pneumoniae) and 0.25 mg/L (H. influenzae). Thiamphenicol shows a good in vitro activity against difficult-to-treat multiply resistant pathogens.(In Vivo):The pharmacokinetics of Thiamphenicol (30 mg/kg) after single intravenous (IV) and oral (PO) administration is investigated in Mulard ducks. After IV administration, for Thiamphenicol, the mean residence time is 2.83 hours, the general half-life is 1.96 hours, the clearance is 0.04 L/hr/kg. Pharmacokinetics after PO administration is very similar for IV administration. Thiamphenicol shows rapid absorption and bioavailability of more than 70%.

Thiamphenicol shows a significant post-antibiotic effect (PAE) (0.33 to 2.9h) on all pathogens studied (S. pneumoniae, S. aureus and Escherichia coli) and a powerful bactericidal effect against β-lactamase-positive and -negative H. influenzae. Thiamphenicol MICs for the microorganisms analyzed are: 32 mg/L (S. aureus and E. coli), 2 mg/L (S. pneumoniae) and 0.25 mg/L (H. influenzae). Thiamphenicol shows a good in vitro activity against difficult-to-treat multiply resistant pathogens.

The pharmacokinetics of Thiamphenicol (30 mg/kg) after single intravenous (IV) and oral (PO) administration is investigated in Mulard ducks. After IV administration, for Thiamphenicol, the mean residence time is 2.83 hours, the general half-life is 1.96 hours, the clearance is 0.04 L/hr/kg. Pharmacokinetics after PO administration is very similar for IV administration. Thiamphenicol shows rapid absorption and bioavailability of more than 70%.

NSC 522822 | (+)-Thiamphenicol | Thiophenicol | WIN 5,603-2

Others

Other Targets

Others

Infection

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15318-45-3

356.22

C12H15Cl2NO5S

>98% (HPLC)

DMSO: 71 mg/mL (199.31 mM)

O=C(N[C@H](CO)[C@H](O)C1=CC=C(S(=O)(C)=O)C=C1)C(Cl)Cl

2,2-dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide

(-20℃)

With Ice Pack

≥ 2 years