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Thapsigargin
CAS No. 67526-95-8
Thapsigargin ( G-202;G 202;G202 )
产品货号. M15579 CAS No. 67526-95-8
A potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Thapsigargin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
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产品描述A potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells; inhibits the Ca2+ ATPase of rat liver ER about 100% at 170 nM, but no inhibition for skeletal muscle SR; increases the concentration of cytosolic free Ca2+ in sensitive cells by an acute and highly specific arrest of the endoplasmic reticulum Ca2+ pump.
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同义词G-202;G 202;G202
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通路Autophagy
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靶点Autophagy
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受体Autophagy
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研究领域Cancer
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适应症——
化学信息
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CAS Number67526-95-8
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分子量650.76
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分子式C34H50O12
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纯度>98% (HPLC)
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溶解度——
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SMILESCCCCCCCC(O[C@@H]1[C@@H](OC(/C(C)=C\C)=O)C(C)=C2[C@@]1([H])[C@@](C)(OC(C)=O)C[C@H](OC(CCC)=O)[C@@]([C@@]3(O)C)(O)[C@@]2([H])OC3=O)=O
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化学全称(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Davidson GA, et al. J Biol Chem. 1995 May 19;270(20):11731-4.
2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.
3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.
4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.
2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.
3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.
4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.
产品手册
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