Thalidomide-NH-C2-PEG3-OH ( H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- )

产品货号. M28647 CAS No. 2140807-23-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Thalidomide-NH-C2-PEG3-OH
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Thalidomide-NH-C2-PEG3-OH 是一种 E3 连接酶配体-接头缀合物。
产品描述

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.
体外实验

XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis.
体内实验

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同义词

H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
通路

Others
靶点

Other Targets
受体

CYP4A|20-Hydroxyeicosatetraenoic acid(20-HETE) synthesis
研究领域

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适应症

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1.Nakamura T, et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6.

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