Tenivastatin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Simvastatin acid (Tenivastatin)，Simvastatin (HY-17502) 的水解产物，是一种有效的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin acid 降低吲哚酚硫酸盐 (Indoxyl sulfate) 介导的活性氧 (ROS) 产生。Simvastatin acid 也可调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。

Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells.Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells.Western Blot Analysis Cell Line:hCM and HEK293 (transfected with OATP3A1) Concentration:0.1, 1, 10 and 20 μM Incubation Time:24 h Result:Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.

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Others

Other Targets

HMG-CoA Reductase | ROS

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121009-77-6

436.58

C25H40O6

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years