Tasosartan

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tasosartan 是血管紧张素 II 2 型 (AT2) 受体的拮抗剂 (IC50 = 1.2 nM)。

Tasosartan is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).

Tasosartan is an orally active nonpeptide AngII antagonist that has demonstrates specific and selective AT1 receptor antagonistic activity in vitro.IC50 for inhibition of specific binding of 125I-AngII to rat adrenal membrane in the absence of proteins in binding buffer is 1.2±0.6 nM.

Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats.

WAY-ANA 756

Endocrinology/Hormones

RAAS

AT2 receptor

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145733-36-4

411.46

C23H21N7O

>98% (HPLC)

DMSO:125 mg/mL (303.80 mM)

Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2

8-((2'-(1H-tetrazol-5-yl)-[11'-biphenyl]-4-yl)methyl)-24-dimethyl-58-dihydropyrido[23-d]pyrimidin-7(6H)-one

(-20℃)

With Ice Pack

≥ 2 years