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Talniflumate

CAS No. 66898-62-2

Talniflumate ( Talniflumate )

产品货号. M18975 CAS No. 66898-62-2

他尼氟酯是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻断剂,可减少动物模型和细胞培养物中粘蛋白的合成和释放。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥356 有现货
5MG ¥567 有现货
10MG ¥794 有现货
25MG ¥1555 有现货
50MG ¥2560 有现货
100MG ¥3831 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Talniflumate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    他尼氟酯是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻断剂,可减少动物模型和细胞培养物中粘蛋白的合成和释放。
  • 产品描述
    Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.(In Vivo):Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction.
  • 体外实验
    ——
  • 体内实验
    Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction. Animal Model:CF mice with distal intestinal obstructive syndrome (DIOS)Dosage:0.4 mg/g Administration:Oral chow; 21 days Result:Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
  • 同义词
    Talniflumate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    hCLCA1/mCLCA3|COX|Cl-/HCO3- exchanger|GCNT3
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    66898-62-2
  • 分子量
    414.33
  • 分子式
    C21H13F3N2O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 62.5 mg/mL (150.85 mM)
  • SMILES
    FC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
  • 化学全称
    2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62.
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