Talniflumate ( Talniflumate )

产品货号. M18975 CAS No. 66898-62-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Talniflumate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture.
产品描述

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
同义词

Talniflumate
通路

Others
靶点

Other Targets
受体

hCLCA1/mCLCA3;COX;Cl-/HCO3- exchanger;GCNT3
研究领域

——
适应症

——

CAS Number

66898-62-2
分子量

414.33
分子式

C21H13F3N2O4
纯度

98%
溶解度

——
SMILES

FC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
化学全称

2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester

1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62.

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