
Talniflumate
CAS No. 66898-62-2
Talniflumate ( Talniflumate )
产品货号. M18975 CAS No. 66898-62-2
他尼氟酯是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻断剂,可减少动物模型和细胞培养物中粘蛋白的合成和释放。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥356 | 有现货 |
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5MG | ¥567 | 有现货 |
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10MG | ¥794 | 有现货 |
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25MG | ¥1555 | 有现货 |
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50MG | ¥2560 | 有现货 |
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100MG | ¥3831 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Talniflumate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述他尼氟酯是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻断剂,可减少动物模型和细胞培养物中粘蛋白的合成和释放。
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产品描述Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.(In Vivo):Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction.
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体外实验——
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体内实验Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction. Animal Model:CF mice with distal intestinal obstructive syndrome (DIOS)Dosage:0.4 mg/g Administration:Oral chow; 21 days Result:Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
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同义词Talniflumate
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通路Others
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靶点Other Targets
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受体hCLCA1/mCLCA3|COX|Cl-/HCO3- exchanger|GCNT3
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研究领域——
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适应症——
化学信息
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CAS Number66898-62-2
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分子量414.33
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分子式C21H13F3N2O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 62.5 mg/mL (150.85 mM)
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SMILESFC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
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化学全称2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62.
产品手册




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