TYA-018

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TYA-018 是一种口服有效且高度选择性的 HDAC6 抑制剂。TYA-018 可以保护小鼠的心脏功能。TYA-018 还通过增加与脂肪酸代谢、蛋白质代谢和氧化磷酸化相关的靶标的表达来增强小鼠的能量。

TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation.

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Animal Model:BAG3cKO miceDosage:15 mg/kg Administration:Oral gavage, daily, starting at 2 months old, for 8 weeksResult:Conferred cardioprotection in mice. Significantly reduced Nppb expression to near WT. Reduced fibrosis in BAG3cKO mice, albeit not significantly. partially restored protein expression of FLNC, PINK1, VDAC2, and p62 to amounts similar to WT mice. Significantly reduced the percentage of cardiomyocytes with damaged and reduced sarcomeres in BAG3cKO mice. Significantly reduced mitochondrial content to amounts similar to WT mice.

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Cell Cycle/DNA Damage

HDAC

HDAC

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2653254-31-8

434.87

C15H13ClF2N4O3S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (229.95 mM; 超声助溶 )

O=S(=O)(N(C=1C=CC=C(Cl)C1)CC2=NC=C(S2)C3=NN=C(O3)C(F)F)CC

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(-20℃)

With Ice Pack

≥ 2 years