TT01001
CAS No. 1022367-69-6
TT01001 ( TT-01001; TT 01001; Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate )
产品货号. M27799 CAS No. 1022367-69-6
TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1442 | 有现货 |
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5MG | ¥2211 | 有现货 |
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10MG | ¥3224 | 有现货 |
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25MG | ¥5387 | 有现货 |
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50MG | ¥7671 | 有现货 |
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100MG | ¥10368 | 有现货 |
|
500MG | ¥20817 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TT01001
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.
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产品描述TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.(In Vivo):In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III.
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同义词TT-01001; TT 01001; Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate
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通路Others
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靶点Other Targets
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受体RIP2
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研究领域——
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适应症——
化学信息
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CAS Number1022367-69-6
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分子量376.3
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分子式C15H19Cl2N3O2S
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纯度>98% (HPLC)
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溶解度——
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SMILESCCOC(=O)N1CCC(CC1)NC(=S)Nc1cc(Cl)cc(Cl)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.
产品手册
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