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TT01001

CAS No. 1022367-69-6

TT01001 ( TT-01001; TT 01001; Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate )

产品货号. M27799 CAS No. 1022367-69-6

TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1442 有现货
5MG ¥2211 有现货
10MG ¥3224 有现货
25MG ¥5387 有现货
50MG ¥7671 有现货
100MG ¥10368 有现货
500MG ¥20817 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    TT01001
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.
  • 产品描述
    TT01001 is a selective agonist of mitoNEET and reduces oxidative stress injury and neuronal apoptosis by improving mitochondrial dysfunction. TT01001 can be used in studies about the treatment of type II diabetes.(In Vivo):In type II diabetes model db/db mice, TT01001 improved hyperglycemia, hyperlipidemia, and glucose intolerance, and its efficacy was equivalent to that of pioglitazone, without the pioglitazone-associated weight gain. Mitochondrial complex II + III activity of the skeletal muscle was significantly increased in db/db mice. TT01001 significantly suppressed the elevated activity of the complex II + III.
  • 同义词
    TT-01001; TT 01001; Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    RIP2
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1022367-69-6
  • 分子量
    376.3
  • 分子式
    C15H19Cl2N3O2S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    CCOC(=O)N1CCC(CC1)NC(=S)Nc1cc(Cl)cc(Cl)c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.
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