
TRi-1
CAS No. 246020-68-8
TRi-1 ( —— )
产品货号. M20217 CAS No. 246020-68-8
TRi-1 是胞质硫氧还蛋白还原酶 1 (TXNRD1) 的不可逆抑制剂,IC50 为 12 nM。 TRi-1对于抗癌治疗来说线粒体毒性很小。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥778 | 有现货 |
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5MG | ¥1191 | 有现货 |
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10MG | ¥1847 | 有现货 |
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25MG | ¥3062 | 有现货 |
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50MG | ¥4358 | 有现货 |
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100MG | ¥6302 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称TRi-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TRi-1 是胞质硫氧还蛋白还原酶 1 (TXNRD1) 的不可逆抑制剂,IC50 为 12 nM。 TRi-1对于抗癌治疗来说线粒体毒性很小。
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产品描述TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
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体外实验Western Blot Analysis Cell Line:FaDu cellsConcentration:0.679 and 6.79 μM Incubation Time:6 hResult:Efficiently activated JNK and p38 phosphorylation. Cell Cytotoxicity Assay Cell Line:Leukemia, non-small cell lung, CNS, colon, melanoma, ovarian, renal, prostate and breast cancer cells Concentration:10 nM-100 μM Incubation Time:48 h Result:Displayed potency against every cell line tested, with an average growth inhibition to 50% (GI50) of 6.31 μM.
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体内实验Animal Model:SCID mice bearing established human FaDu cell xenograftsDosage:10 mg/kg Administration:Intravenous injection, twice a day for 4 days Result:Resulted in decreased tumor growth compared to vehicle controls within four days with no signs of overt toxicity or changes in mouse weight relative to vehicle control.Animal Model:PyMT-MMTV mice that spontaneously develop malignant breast cancer tumors.Dosage:5 mg/kg Administration: Intraperitoneal injection, twice a week for 3 weeks Result:Impaired tumor growth, significantly reduced tumor volumes.
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同义词——
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通路Others
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靶点Other Targets
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受体TXNRD1
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研究领域——
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适应症——
化学信息
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CAS Number246020-68-8
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分子量328.72
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分子式C12H9ClN2O5S
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纯度>98% (HPLC)
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溶解度DMSO:62.5 mg/mL?(190.13 mM)
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SMILESCOc1ccc(c(n1)S(=O)(=O)c1ccc(Cl)cc1)[N+]([O-])=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Stafford WC et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.
产品手册




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