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TPI-1
CAS No. 79756-69-7
TPI-1 ( TPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1 )
产品货号. M17598 CAS No. 79756-69-7
TPI-1 is a SHP-1 inhibitor.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥567 | 有现货 |
|
| 5MG | ￥948 | 有现货 |
|
| 10MG | ￥1604 | 有现货 |
|
| 25MG | ￥3135 | 有现货 |
|
| 50MG | ￥4763 | 有现货 |
|
| 100MG | ￥6788 | 有现货 |
|
| 500MG | ￥13932 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TPI-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TPI-1 is a SHP-1 inhibitor.
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产品描述TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
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同义词TPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1
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通路Others
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靶点Other Targets
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受体recombinant SHP-1
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研究领域Cancer
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适应症——
化学信息
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CAS Number79756-69-7
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分子量253.08
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分子式C12H6Cl2O2
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纯度98%
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溶解度DMSO : 50 mg/mL 197.57 mM;
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SMILESc1cc(c(cc1Cl)C1=CC(=O)C=CC1=O)Cl
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化学全称2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.
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