TP455

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TP455 (TP-455) 是一种高效、选择性 A2A 腺苷受体反向激动剂，在 hA2A CHO 细胞中进行环 AMP 测定时，IC50 为 1.9 nM。

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells; TP455 proved to be more potent than morphine in writhing and tail immersion tests in mice with ED50 of 0.0328 mg/kg, exhibits great analgesic activity with an ED50 of 0.134 ± 0.011 mg/kg and minimum effective dose of 0.01 mg/kg; antagonizes CGS 21680-induced cell proliferation in cancer cell lines, inhibits GS 21680-dependent pERK1/2, pJNK MAPK kinase, and pAKT activation.

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TP-455 | TP 455

Apoptosis

Adenosine Receptor

Adenosine Receptor

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2042563-95-9

353.4

C17H15N5O2S

>98% (HPLC)

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COC1=CC=CC=C1CNC2=NC(=C3C(=N2)SC(=N3)C4=CC=CO4)N

2-(2-furanyl)-N5-(2-methoxybenzyl)[1,3]thiazolo[5,4-d]pyrimidine-5,7-diammine

(-20℃)

With Ice Pack

≥ 2 years