TMX-4100 ( ——— )

产品货号. M39457 CAS No. 2367619-63-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TMX-4100
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TMX-4100 是一种选择性磷酸二酯酶 6D (PDE6D) 降解剂。TMX-4100 在 MOLT4、Jurkat 和 MM.1S 肿瘤细胞中表现出对 PDE6D 的高降解偏好，DC50 值小于 200 nM。TMX-4100 可用于多发性骨髓瘤的研究。
产品描述

TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
体外实验

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体内实验

TMX-4100 (compound 3；1 μM；4 h) 在 MOLT4 细胞中表现出对 PDE6D 的高度降解偏好。与 PDE6D 降解剂 FPFT-2216 相比，TMX-4100 在 MOLT4 细胞中具有更好的全蛋白质组降解选择性。 TMX-4100 不会阻碍 KRAS 依赖性细胞系 (MIA PaCa-2、NCI-H358、AGS、PA-TU-8988T ) 的生长。Western Blot Analysis Cell Line:MOLT4 cells Concentration:1 μM Incubation Time:4 hours Result:Showed a high degradation preference for PDE6D.Western Blot Analysis Cell Line:MOLT4, Jurkat, and MM.1S cells Concentration:0 nM, 40 nM, 200 nM, 1 μM;Incubation Time:4 hours Result:Showed a high degradation preference for PDE6D with the DC50 value less than 200 nM.
同义词

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通路

Others
靶点

Other Targets
受体

PDE6D
研究领域

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适应症

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1. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.?

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