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TMN355
CAS No. 1186372-20-2
TMN355 ( —— )
产品货号. M22935 CAS No. 1186372-20-2
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1191 | 有现货 |
|
| 10MG | ￥1847 | 有现货 |
|
| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4982 | 有现货 |
|
| 100MG | ￥7096 | 有现货 |
|
| 500MG | ￥14418 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TMN355
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.
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产品描述TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion,and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL.?The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p同义词——通路Others靶点Other Targets受体cyclophilin A研究领域——适应症——
化学信息
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CAS Number1186372-20-2
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分子量380.8
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分子式C21H14ClFN2O2
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纯度>98% (HPLC)
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溶解度DMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)
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SMILESO=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.
产品手册
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