
TLR7-agonist-1
CAS No. 1642857-69-9
TLR7-agonist-1 ( —— )
产品货号. M18104 CAS No. 1642857-69-9
TLR7-agonist-1 是一种特异性有效的 Toll 样受体 7 (TLR7) 激动剂 (LEC=0.4 μM)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥2049 | 有现货 |
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5MG | ¥4228 | 有现货 |
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10MG | ¥6116 | 有现货 |
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25MG | ¥9477 | 有现货 |
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50MG | ¥12798 | 有现货 |
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100MG | ¥17253 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称TLR7-agonist-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TLR7-agonist-1 是一种特异性有效的 Toll 样受体 7 (TLR7) 激动剂 (LEC=0.4 μM)。
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产品描述TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
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体外实验TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) of 0.4 μM in HEK293 cell. TLR7 agonist 2 is found to be selective for TLR7 over TLR8 with LEC of >100 μMfor human TLR8. TLR7 agonist 2 demonstrates low inhibition across five CYP450 isozymes (IC50 >10 μM) and is also not a time dependent inhibitor of CYP450 3A4. TLR7 agonist 2 has limited inhibition of the hERG potassium ion channel 3H-dofetilide binding in vitro (IC50 >50 μM).
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体内实验TLR7 agonist 2 is found to be rapidly cleared in conjunction with our target profile. Both Cmax and AUC increase less than dose proportionally between 0.3 and 3 mg/kg and more than dose-proportionally between 3 and 10 mg/kg. TLR7 agonist 2 can induce an antiviral interferon stimulated gene (ISG) response without inducing an IFNα response at a low dose. TLR7 agonist 2 also induces a 2.7 log decrease in serum HBV viral load from 0.3 mg/kg, and a maximum 3.1 log decrease is observed for doses between 1 and 5 mg/kg.
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同义词——
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通路Others
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靶点Other Targets
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受体TLR7
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研究领域Infection|Inflammation/Immunology
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适应症——
化学信息
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CAS Number1642857-69-9
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分子量336.36
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分子式C17H16N6O2
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纯度>98% (HPLC)
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溶解度DMSO : 160 mg/mL 475.69 mM;
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SMILESCC1=CC(=NO1)COC2=NC(=NC3=C2N(C=C3)CC4=CC=CC=N4)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.McGowan DC, et al.. J Med Chem. 2017 Jul 27;60(14):6137-6151.
产品手册




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