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TH5487
CAS No. 2304947-71-3
TH5487 ( —— )
产品货号. M21183 CAS No. 2304947-71-3
TH5487 是 8-氧鸟嘌呤 DNA 糖基化酶 1 (OGG1) 的有效抑制剂（IC50 为 342 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥462 | 有现货 |
|
| 5MG | ￥770 | 有现货 |
|
| 10MG | ￥1320 | 有现货 |
|
| 25MG | ￥2584 | 有现货 |
|
| 50MG | ￥4682 | 有现货 |
|
| 100MG | ￥6747 | 有现货 |
|
| 500MG | ￥13689 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TH5487
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TH5487 是 8-氧鸟嘌呤 DNA 糖基化酶 1 (OGG1) 的有效抑制剂（IC50 为 342 nM）。
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产品描述TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM).
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体外实验RT-PCR Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs) Concentration:5 μM Incubation Time:1 hour Result:Inhibited proinflammatory gene expression dose-dependently.Western Blot Analysis Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs)Concentration:2.5 μM; 5 μM; 10 μM Incubation Time:1 hour Result:Decreased p50-p65 and p50-p50 expression in a dose dependent manner.
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体内实验Animal Model:Eightweek-old female and male BALB/c mice Dosage:8 mg/kg, 15 mg/kg, 30 mg/kg Administration:Prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours Result:Interrupted TNFα-induced ongoing inflammatory processes.
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同义词——
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通路Others
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靶点Other Targets
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受体8-oxoguanine DNA glycosylase 1 (OGG1)
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研究领域——
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适应症——
化学信息
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CAS Number2304947-71-3
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分子量541.18
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分子式C19H18BrIN4O2
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纯度>98% (HPLC)
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溶解度DMSO:25 mg/mL (46.20 mM; Need ultrasonic)
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SMILESO=C(Nc1ccc(I)cc1)N1CCC(n2c(=O)[nH]c3c(Br)cccc32)CC1
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化学全称4-(4-Bromo-23-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Visnes T et al. Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science. 2018 Nov 16;362(6416):834-839.
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