TH5427

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TH5427 是一种先导 NUDT5 抑制剂（MG 测定 IC50 = 29 nM）。

TH5427 is a lead NUDT5 inhibitor(MG assay IC50?=?29?nM).(In Vitro):In HL-60 cell lysates, TH5427(20?μM) stabilized NUDT5 to nearly the same levels as observed in the 37?°C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1?μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to?≈?8?°C).

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Others

Other Targets

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2253744-56-6

491.33

C20H20Cl2N8O3

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (10.18 mM)

CN(c1c(C(N2C)=O)n(Cc3nnc(-c(cc4)cc(Cl)c4Cl)o3)c(N3CCNCC3)n1)C2=O

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(-20℃)

With Ice Pack

≥ 2 years