021-51111890
购物车（）
sales@molnova.cn
TH5427
CAS No. 2253744-56-6
TH5427 ( —— )
产品货号. M28237 CAS No. 2253744-56-6
TH5427 是一种先导 NUDT5 抑制剂（MG 测定 IC50 = 29 nM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2041 | 有现货 |
|
| 5MG | ￥3143 | 有现货 |
|
| 10MG | ￥4674 | 有现货 |
|
| 25MG | ￥7501 | 有现货 |
|
| 50MG | ￥10206 | 有现货 |
|
| 100MG | ￥13608 | 有现货 |
|
| 500MG | ￥27378 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称TH5427
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述TH5427 是一种先导 NUDT5 抑制剂（MG 测定 IC50 = 29 nM）。
-
产品描述TH5427 is a lead NUDT5 inhibitor(MG assay IC50?=?29?nM).(In Vitro):In HL-60 cell lysates, TH5427(20?μM) stabilized NUDT5 to nearly the same levels as observed in the 37?°C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1?μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to?≈?8?°C).
-
体外实验——
-
体内实验——
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number2253744-56-6
-
分子量491.33
-
分子式C20H20Cl2N8O3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 5 mg/mL (10.18 mM)
-
SMILESCN(c1c(C(N2C)=O)n(Cc3nnc(-c(cc4)cc(Cl)c4Cl)o3)c(N3CCNCC3)n1)C2=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Villalva M, et al. Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract. J Agric Food Chem. 2018 Feb 7;66(5):1167-1174.
产品手册
关联产品
-
AKOS025692697
AKOS025692697 是一种生化物质。
-
4-Chlorocinnamic aci...
4-Chlorocinnamic acid is a photosensitive compound. 2-Chlorocinnamic acid and 4-chlorocinnamic acid show potent urease inhibitory activities with the respective IC50 values of 0.66 and 1.10 uM.
-
(15alpha,20Z)-15-hyd...
15a-Hydroxy-3,11,23-trioxo-lanost-8,20-dien-26-oic acid is a Lanostane triterpenoid compound with the ability to inhibit NO production in LPS-induced microglia.
