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TH5427
CAS No. 2253744-56-6
TH5427 ( —— )
产品货号. M28237 CAS No. 2253744-56-6
TH5427 is a lead NUDT5 inhibitor(MG assay IC50?=?29?nM).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2041 | 有现货 |
|
| 5MG | ￥3143 | 有现货 |
|
| 10MG | ￥4674 | 有现货 |
|
| 25MG | ￥7501 | 有现货 |
|
| 50MG | ￥10206 | 有现货 |
|
| 100MG | ￥13608 | 有现货 |
|
| 500MG | ￥27378 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TH5427
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TH5427 is a lead NUDT5 inhibitor(MG assay IC50?=?29?nM).
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产品描述TH5427 is a lead NUDT5 inhibitor(MG assay IC50?=?29?nM).(In Vitro):In HL-60 cell lysates, TH5427(20?μM) stabilized NUDT5 to nearly the same levels as observed in the 37?°C DMSO control. TH5427 was the most potent stabilizer under the described conditions with an apparent EC50 of 2.1?μM. Accordingly, TH5427 had a positive, dose-dependent shift in the apparent Tagg—the temperature at which 50 % of the target protein denatures and aggregates (TH5427 shifted NUDT5 Tagg up to?≈?8?°C).
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number2253744-56-6
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分子量491.3
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分子式C20H20Cl2N8O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCN(c1c(C(N2C)=O)n(Cc3nnc(-c(cc4)cc(Cl)c4Cl)o3)c(N3CCNCC3)n1)C2=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Villalva M, et al. Anti-Inflammatory and Antioxidant Activities from the Basolateral Fraction of Caco-2 Cells Exposed to a Rosmarinic Acid Enriched Extract. J Agric Food Chem. 2018 Feb 7;66(5):1167-1174.
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