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TGFβRI-IN-3

CAS No. 2763602-67-9

TGFβRI-IN-3 ( —— )

产品货号. M37631 CAS No. 2763602-67-9

TGFβRI-IN-3 抑制 TGFβR1 的 IC50 为 0.79 nM,选择性是 MAP4K4 的 2000 倍。TGFβRI-IN-3 是一种高选择性 TGFβR1 抑制剂,在免疫肿瘤中有潜在的应用价值。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1034 有现货
5MG ¥1591 有现货
10MG ¥2527 有现货
25MG ¥4794 有现货
50MG ¥7468 有现货
100MG ¥10481 有现货
500MG ¥20885 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    TGFβRI-IN-3
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    TGFβRI-IN-3 抑制 TGFβR1 的 IC50 为 0.79 nM,选择性是 MAP4K4 的 2000 倍。TGFβRI-IN-3 是一种高选择性 TGFβR1 抑制剂,在免疫肿瘤中有潜在的应用价值。
  • 产品描述
    TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    TGF-beta/Smad
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    2763602-67-9
  • 分子量
    465.57
  • 分子式
    C28H23N3O2S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO 中的溶解度 : 50 mg/mL (107.40 mM; 超声助溶 (<60°C)
  • SMILES
    N(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.?
产品手册
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