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TED-347
CAS No. 2378626-29-8
TED-347 ( —— )
产品货号. M21960 CAS No. 2378626-29-8
TED-347 是 TEAD4-Yap1 蛋白质-蛋白质相互作用的不可逆共价抑制剂（EC50 为 5.9 μM），并抑制胶质母细胞瘤细胞活力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥940 | 有现货 |
|
| 10MG | ￥1596 | 有现货 |
|
| 25MG | ￥3216 | 有现货 |
|
| 50MG | ￥4836 | 有现货 |
|
| 100MG | ￥7031 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TED-347
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TED-347 是 TEAD4-Yap1 蛋白质-蛋白质相互作用的不可逆共价抑制剂（EC50 为 5.9 μM），并抑制胶质母细胞瘤细胞活力。
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产品描述TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
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体外实验Cell Viability Assay Cell Line:GBM43 glioblastoma cell lines Concentration:0.5, 1, 10, 100 μM Incubation Time:48 hoursResult:Inhibited GBM43 cancer cell viability and inhibited GBM43 cell viability by 30% at 10 μM.Western Blot Analysis Cell Line:HEK-293 cells Concentration:5 μM Incubation Time:48 hours Result:Showed a significant loss of co-immunoprecipitation of Myc-tagged TEAD4 with FLAG-tagged Yap1.RT-PCRCell Line:HEK-293 cells Concentration:10 μM Incubation Time:48 hours Result:Showed a significant reduction in CTGF transcript levels versus control cells and had no inhibition on TEAD mutant transcriptional activity and protein-protein interactions in cell culture.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体TEAD4-Yap1
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研究领域——
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适应症——
化学信息
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CAS Number2378626-29-8
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分子量313.7
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分子式C15H11ClF3NO
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纯度>98% (HPLC)
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溶解度DMSO:64 mg/ml(204.02 mM)
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SMILESFC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
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