TCN-201

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TCN-201 是含有 NR2A 亚基的 NMDA 受体选择性拮抗剂。

TCN-201 is a selective antagonist of NMDA receptors containing the NR2A subunit.

TCN 201 (compound 1) is selective for GluN1/GluN2A NMDAR over GluN1/GluN2B NMDAR, with pIC50s of 6.8 and <4.3, respectively.TCN 201 (10 μM) produces only slight inhibition of GluN1/GluN2B NMDAR-mediated currents in oocytes.TCN 201 (10-30 μM) antagonism of NMDAR-mediated responses is both subtype- and glycine-dependent and more potent than TCN 213 in oocytes.TCN 201 (0.1-100 μM) does not produce complete block of NMDAR-mediated responses in oocytes.TCN 201 (10 μM) antagonism of NMDAR-mediated currents shows a negative correlation with their ifenprodil sensitivity in rat cortical neurons.TCN 201 (1-9 μM) suppresses cortical spreading depression (CSD) in chick retina.

TCN-201 (10 mg/kg; i.p.) is ineffective in CSD blood-oxygen level-dependent (BOLD) response in rats.

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Membrane Transporter/Ion Channel

NMDAR

NMDA receptor

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852918-02-6

461.89

C21H17ClFN3O4S

>98% (HPLC)

DMSO:20mg/ml(43.3mM)

O=C(NNC(=O)c1ccc(CNS(=O)(=O)c2ccc(F)c(Cl)c2)cc1)c1ccccc1

4-[[[(3-chloro-4-fluorophenyl)sulfonyl]amino]methyl]-benzoic acid 2-benzoylhydrazide

(-20℃)

With Ice Pack

≥ 2 years