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TCA-1

CAS No. 864941-32-2

TCA-1 ( TCA1 )

产品货号. M16276 CAS No. 864941-32-2

具有抗耐药性和持续性结核病活性的小分子;在体外显示出针对非复制 Mtb 的杀菌活性,并且在急性和慢性 Mtb 感染小鼠模型中有效。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥510 有现货
5MG ¥786 有现货
10MG ¥1256 有现货
25MG ¥2325 有现货
50MG ¥3548 有现货
100MG ¥5257 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    TCA-1
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    具有抗耐药性和持续性结核病活性的小分子;在体外显示出针对非复制 Mtb 的杀菌活性,并且在急性和慢性 Mtb 感染小鼠模型中有效。
  • 产品描述
    A small molecule with activity against drug-resistant and persistent tuberculosis; shows bactericidal activity against nonreplicating Mtb in vitro and is efficacious in acute and chronic Mtb infection mouse models; down-regulates genes known to be involved in Mtb persistence; inhibits DprE1 and MoeW, enzymes involved in cell wall and molybdenum cofactor biosynthesis.
  • 体外实验
    TCA1 shows bactericidal activity against both replicating (WT and drug resistant) and nonreplicating Mycobacterium tuberculosis (Mtb). TCA1 inhibits biofilm formation by Mtb H37Rv. TCA1 shows selective inhibitory activity against bacterial growth-it is inactive against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, suggesting that the target for its bactericidal activity is specific to the genus Mycobacterium.
  • 体内实验
    TCA1 (40 mg/kg; oral gavage; 1 time/d for 5 d/week; for 4 weeks) is efficacious in acute and chronic Mtb infection mouse models.In a mouse model of Mtb infection, after i.v. administration, TCA1 exhibits a low clearance and steady-state volume of distribution, with an elimination half-life of 0.73 h. After oral administration of 20 and 50 mg/kg in solution formulation, TCA1 shows a high Cmax (2122 and 5653 nM, respectively), moderate exposure with oral bioavailability ranging from 19% to 46%, and a half-life of 1.8 h.
  • 同义词
    TCA1
  • 通路
    GPCR/G Protein
  • 靶点
    Antibacterial
  • 受体
    Antibacterial
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    864941-32-2
  • 分子量
    375.417
  • 分子式
    C16H13N3O4S2
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: Soluble ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    CCOC(=O)NC(=O)C1=C(SC=C1)NC(=O)C2=NC3=CC=CC=C3S2
  • 化学全称
    ethyl (2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Wang F, et al. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7.
产品手册
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